ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gynecological Oncology
This article is part of the Research TopicAdvances in Diagnosis and Treatment of Endometrial CancerView all 22 articles
Human Epidermal Growth Factor Receptor 2 Expression in Gynecologic Serous Carcinomas and Preliminary Analysis of Its Characteristics in Patients Post-neoadjuvant chemotherapy
Provisionally accepted
- Department of Pathology, Peking University People’s Hospital, Beijing, China
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Objectives: To investigate HER2 status in uterine (USC) and ovarian high-grade serous carcinoma (HGSC), compare ASCO/CAP and ISGyP interpretation criteria, and analyze prognostic significance. Methods: We retrospectively analyzed 51 USC and 165 ovarian HGSC cases. HER2 was assessed by IHC using ASCO/CAP (2023) and ISGyP criteria, with FISH validation. Survival analysis was performed. Results: HER2 amplification rates were 29.4% in USC, 4.9% in primary ovarian HGSC, and 7.0% in post-neoadjuvant HGSC. HER2 3+ rates were similar between criteria, but ISGyP identified more HER2-low cases. HER2 positivity correlated with worse prognosis in ovarian HGSC. Conclusion: HER2-positive and HER2-low cases exist in serous carcinomas. ISGyP criteria are more sensitive for HER2-low. HER2 status provides prognostic and therapeutic implications.
Keywords: fish, HER2, Ovarian high-grade serous carcinoma, targeted therapy, uterine serous carcinoma
Received: 25 Apr 2025; Accepted: 08 Dec 2025.
Copyright: © 2025 Liu, Cheng, Kong and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Danhua Shen
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