MINI REVIEW article
Front. Oncol.
Sec. Radiation Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1619097
This article is part of the Research TopicInnovative Approaches in Precision Radiation OncologyView all 12 articles
Dual Regulation of the cGAS-STING Pathway: New Targets and Challenges for Subtype-Specific Immunotherapy in Breast Cancer
Provisionally accepted
- Zhejiang Provincial People's Hospital, Hangzhou, China
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Research on immune regulation mechanisms in breast cancer is crucial for breaking through therapeutic bottlenecks. This paper comprehensively reviews the dual roles of the cGAS-STING pathway in Luminal, HER2+, and triple-negative breast cancer (TNBC): its activation can enhance antitumor immunity, but chronic activation may lead to immunosuppression. By integrating molecular mechanisms, clinical translation, and subtype-specific strategies, it provides new directions for precision immunotherapy.
Keywords: CGAS, STING, breast cancer, tumor mic roenvironment, Innate immunity
Received: 27 Apr 2025; Accepted: 15 May 2025.
Copyright: © 2025 Xiong, Li, Yang, Li and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiao Ma, Zhejiang Provincial People's Hospital, Hangzhou, China
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