CASE REPORT article
Front. Oncol.
Sec. Surgical Oncology
Metastatic Benign Fibrous Histiocytoma: A Case Series and Review of Diagnostic and Therapeutic Challenge
Provisionally accepted
- 1Fudan University Shanghai Cancer Center, Shanghai, China
- 2Fudan University Shanghai Cancer Center Xiamen Hospital, Shanghai, China
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Background: Benign Fibrous Histiocytoma (BFH), also known as dermatofibroma, is a common benign mesenchymal tumor of the skin. Although typically non-aggressive, rare cases of metastatic BFH pose diagnostic and therapeutic challenges. Methods: This study reviews 10 cases of metastatic BFH diagnosed at Fudan University Shanghai Cancer Center between 2009 and 2024, with a detailed examination of three cases involving recurrent and metastatic behavior. Immunohistochemical markers and radiological imaging findings were analyzed to characterize tumor progression and treatment responses. Results: The cases highlighted distinct patterns of recurrence and metastasis, including lymphatic and distant organ involvement. Immunohistochemical analysis demonstrated variable expression of markers such as Vimentin, CD68, CD163, Ki67, and SMA. Conclusions: Metastatic BFH remains a rare but clinically significant condition. Early recognition, accurate histopathological diagnosis, and multimodal therapies are crucial for effective management.
Keywords: Benign fibrous histiocytoma, metastasis, Recurrence, case report, Treatment
Received: 01 May 2025; Accepted: 24 Oct 2025.
Copyright: © 2025 Liu, Sun, Wu, Ye, Wang, Sun and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chunmeng Wang, cmwang1975@163.com
Yangbai Sun, drsunyb@fudan.edu.cn
Wangjun Yan, yanwj@fudan.edu.cn
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