ORIGINAL RESEARCH article
Front. Oncol.
Sec. Genitourinary Oncology
This article is part of the Research TopicUrothelial Neoplasms: An Integrated Approach to Prevention, Diagnostics, and Personalized TherapyView all 17 articles
Brachytherapy stents versus conventional plastic stents for the treatment of malignant ureteral obstruction: initial experience
Provisionally accepted
- The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
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Abstract Objective: To evaluate the feasibility of a newly designed integrated plastic stent loaded with radioactive 125I seeds (brachytherapy stent) for the treatment of malignant ureteral obstruction (MUO). Methods: From May 2018 to May 2023, 30 patients with MUO underwent brachytherapy plastic stent placement (experimental group), while 41 patients underwent conventional plastic stent placement (control group). The primary endpoints were technical success, complications, the local disease response rate (DRR) and the gross haematuria control (GHC) rate; the secondary endpoints were the hydronephrosis Girignon score (HGC) and overall survival (OS). Results: The rates of technical success (100% vs. 100%), complications (26.7% vs. 14.6%) and HGC (1.5±0.5) vs. (1.5±0.5) in the experimental and control groups were not significantly different (p>0.05). The DRR (93.3% vs. 9.8%) and GHC rates (84.2% vs. 20.8%) of the experimental and control groups at 8 weeks were statistically significant (P<0.05). The OS [28.4 month (95% CI: 24.6–32.3) vs. 19.5 month (95% CI: 17.0–22.0)] of the experimental and control groups was significantly different (P<0.05). Conclusion: This novel brachytherapy stent is safe and effective for the treatment of MUO, but long term follow up is needed. Keywords: 125I seeds; Brachytherapy; Stent; Malignant ureteral obstruction; Interventional radiology
Keywords: 125I seeds, Brachytherapy, interventional radiology, malignant ureteral obstruction, stent
Received: 09 May 2025; Accepted: 05 Dec 2025.
Copyright: © 2025 Li, Zhang, Song, Sun, Han, Zhou and Jiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xueliang Zhou
Dechao Jiao
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