REVIEW article
Front. Oncol.
Sec. Molecular and Cellular Oncology
This article is part of the Research TopicE3 Ubiquitin Ligases: Critical Roles in Cancer Progression and Therapeutic ImplicationsView all 6 articles
Roles of E3 Ubiquitin Ligases and Deubiquitinating Enzymes in Renal Cell Carcinoma
Provisionally accepted
- 1Guangdong Medical University, Zhanjiang, China
- 2Department of Oncology Medical Center,The First People's Hospital of Zhaoqing, Zhaoqing, China
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Ubiquitination is an important post-translational modification of proteins that precisely regulates protein stability and function through the coordinated actions of E3 ubiquitin ligases (E3s) and deubiquitinases (DUBs), participating in biological processes including protein degradation and signal transduction. In recent years, the role of ubiquitination modification in the carcinogenesis, progression, and treatment of renal cell carcinoma (RCC) has garnered increasing attention. This review summarizes the structural classifications of key enzymes in the ubiquitination process—E3s and DUBs — and to discuss their specific molecular mechanisms in RCC. Finally, we discuss the targeted therapeutic strategies focusing on these key ubiquitination-modifying enzymes in RCC.
Keywords: E3 ubiquitin ligases, Deubiquitinating enzymes, Ubiquitination, Renal CellCarcinoma, Enzymes, targeted therapy
Received: 27 May 2025; Accepted: 11 Dec 2025.
Copyright: © 2025 Jiang, Quan, Si, Zhang, Huan and Qu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yi Quan
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