ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gynecological Oncology
Prevalence and risk factors of frailty in patients with gynecological malignancies after surgery and chemotherapy: a cross-sectional study
Provisionally accepted
- 1The Third Hospital of Hebei Medical University, Shijiazhuang, China
- 2Shanghai First Maternity and Infant Hospital, Shanghai, China
- 3School of Medicine, Tongji University, Shanghai, China
- 4School of Nursing and Health Studies, Hong Kong Metropolitan University, Hong Kong, China
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Purpose: Frailty is a significant factor influencing the prognosis of patients with gynecological malignancies. Surgery and chemotherapy are key components of cancer treatment; however, limited research has addressed frailty and its associated risk factors in this patient population. This study aimed to determine the prevalence of frailty and identify its associated factors in patients with gynecological malignancies following surgery and chemotherapy. Method: This cross-sectional study was conducted at two tertiary hospitals in Shanghai between January and September 2024. Patients completed five assessment scales, including the Demographic Information Scale, Vulnerable Elders Survey-13 (VES-13), Athens Insomnia Scale (AIS), Depression Anxiety Stress Scale-21 (DASS-21), and Perceived Social Support Scale (PSSS), to screen for frailty and related factors. Multivariate logistic regression analysis was used to identify risk factors for frailty, with 95% confidence intervals (CIs) used to estimate the strength of the associations. Result: A total of 211 eligible inpatients with gynecological malignancies who had undergone surgery and chemotherapy were recruited. The prevalence of frailty in these patients was 64.9%. Multivariate logistic regression analysis identified several risk factors for frailty: older age, underweight status, stress, insomnia, married status, high white blood cell count, and low albumin levels. Conclusion: This study highlights the relatively high prevalence of frailty among patients with gynecological malignancies after surgery and chemotherapy. Understanding the factors associated with frailty is crucial for implementing timely interventions that can improve health-related quality of life and treatment outcomes in this patient population.
Keywords: chemotherapy, Cross-sectional study, Frailty, Gynecological oncology, Surgery
Received: 15 May 2025; Accepted: 10 Dec 2025.
Copyright: © 2025 Song, Wang, Liu and Duan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xia Duan
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