REVIEW article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1629495
This article is part of the Research TopicGut Microbiota and Local Immune System in Colorectal and Liver CancerView all 4 articles
The Role of Gut Microbiome in Colorectal Cancer Development: A Comprehensive Analysis Based on Metabolomics and Immunomodulatory Mechanisms
Provisionally accepted
- The First Affiliated Hospital of China Medical University, Shenyang, China
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With shifts in lifestyle and dietary habits, the incidence of colorectal cancer has been rising annually, with an increasing prevalence among younger populations, thereby imposing a significant burden on global health. Although the rate of early diagnosis for colorectal cancer has improved due to the widespread use of gastrointestinal endoscopy, many patients still do not experience substantial improvements in survival rates or quality of life. Consequently, there is a pressing need for further in-depth research into the pathogenesis of colorectal cancer, as well as the exploration of potential methods for early diagnosis and precise treatment. As research into the gut microbiome system advances, its remarkable efficacy in the early diagnosis, treatment, and prognosis assessment of various diseases has garnered considerable attention. Variations in the gut microbiome among individuals may result in differential immune responses to specific pathogens or treatment modalities. This article reviews the interaction mechanisms between gut microbiota and immune cells in colorectal cancer, integrating the latest research findings in the field, with the aim of providing potential directions and theoretical foundations for the development of personalized immunotherapy.
Keywords: colorectal cancer, gut microbiome, Immunomodulation, Carcinogenesis, Wnt/ β -catenin Signaling
Received: 15 May 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Liu, Xu and Wen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shu Liu, The First Affiliated Hospital of China Medical University, Shenyang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.