ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1631979
Preoperative prognostic assessment using Intratumoral and Peritumoral Adipose Tissue Radiomics derived from Contrast-Enhanced CT in cT3-4 Gastric Cancer
Provisionally accepted
- Department of Medical Imaging, Jiangsu University Affiliated People's Hospital, Zhenjiang, China
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Purpose Exploring the value of contrast-enhanced computed tomography (CECT) based radiomics features from intratumoral and peritumoral adipose tissue (PAT) in predicting early recurrence (ER) after gastrectomy in patients with cT3-4 gastric cancer (GC). Materials and methods This retrospective study involved patients with cT3-4 GC who underwent preoperative CECT. The radiomics features of tumor and PAT were separately extracted from the CT venous phase images using the Pyradiomics package. The radiomic score (radscore) was computed for each patient by integrating LASSO regression-selected radiomic features, weighted according to their respective coefficients. The GC location , longest diameter , maximum thickness , cT stage and cN stage determined by preoperative CT were also evaluated. Univariate and bivariate analyses using the Cox regression model were performed to evaluate factors affecting ER. The Kaplan-Meier method was used for the analysis of ER-free survival. Results A total of 184 consecutive cT3-4 GC patients were enrolled in this study. Bivariate Cox regression analyses demonstrated that radscore and cT stage emerged as independent predictors of ER in all parameters. Radscore-based stratification showed a marked difference in the ER rates between high-risk patients (radscore ≥ -0.66) and low-risk patients (65.9% vs. 3.2%; log-rank p<0.001). Similarly, cT4 stage patients had markedly higher ER rates than cT3 stage patients (53.5% vs. 22.1%; log-rank p<0.001). Conclusion The integrated radscore combining intratumoral and PAT features emerged as an independent prognostic predictor for ER in cT3-4 GC, offering quantitative biomarkers to optimize neoadjuvant therapy selection and postoperative surveillance intensity.
Keywords: gastric cancer, Contrast-enhanced computed tomography, Radiomics, prognosis, peritumoral adipose tissue
Received: 20 May 2025; Accepted: 25 Sep 2025.
Copyright: © 2025 Chao, Donggang, Xiuhong, Dai, Bowen, Zhixuan and Xiaoxiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shan Xiuhong, 13913433095@163.com
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