REVIEW article
Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1632060
IQGAP1: Cross-Disease Target via Receptor-Pathway Networks
Provisionally accepted
Shaopeng Zhu1
Yunpeng Zou1
Jie Guo2Wenqi Ma2Laitong Lu2
Ronghan Liu2
Jianning Kang2
Kai Zhao2*Jiangbo Zhong2*- 1Shandong Second Medical University, Weifang, Shandong Province, China
- 2Jinan Central Hospital, Jinan, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
IQGAP1, a versatile scaffolding protein, critically regulates cytoskeletal organization, cell motility, proliferation, and signaling cascades. Beyond coordinating these cellular functions, it is increasingly recognized as a key driver in malignancies, immune dysfunction, metabolic dysregulation, and cardiovascular pathologies. By binding receptor tyrosine kinases, small GTPases, and downstream effectors, IQGAP1 modulates oncogenesis, immune evasion, and metabolic imbalance, while contributing to chemoresistance. This review synthesizes advances in IQGAP1’s structural domains, disease-specific signaling networks, and therapeutic targeting strategies, emphasizing its translational potential in developing precision therapies for cancer, metabolic syndromes, and immune disorders.
Keywords: IQGAP1, Scaffold protein, Cancer, Drug Resistance, Immune Modulation, Metabolic Diseases, Cell signaling, Therapeutic target
Received: 21 May 2025; Accepted: 01 Sep 2025.
Copyright: © 2025 Zhu, Zou, Guo, Ma, Lu, Liu, Kang, Zhao and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kai Zhao, Jinan Central Hospital, Jinan, China
Jiangbo Zhong, Jinan Central Hospital, Jinan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.