CASE REPORT article
Front. Oncol.
Sec. Gynecological Oncology
Adenoid basal carcinoma of the uterine cervix:a case report
Provisionally accepted
Yuan Tan1
Liqin Lai2*- 1Pathology, Tongde Hospital of Zhejiang Province, Hangzhou, China
- 2Tongde Hospital of Zhejiang Province, Hangzhou, China
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Background :Adenoid basal carcinoma (ABC) is a rare human papillomavirus (HPV)-related malignancy of the uterine cervix that predominantly affects postmenopausal women and it is a low-grade tumor with a favorable prognosis. This report presents a case of ABC along with a detailed immunohistochemical analysis. Case presentation: A 65-year-old woman tested positive for HPV types 16, 35, and 56 during routine screening. Subsequent cervical biopsy indicated adenocarcinoma. The patient was asymptomatic. She underwent radical hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic lymph node dissection. Comprehensive pathological examination of the hysterectomy specimen confirmed ABC with a focal component of high-grade squamous intraepithelial lesion (HSIL). The postoperative course was uneventful, and no recurrence or metastasis was observed during four years of follow-up. Conclusion: Adequate tissue sampling and appropriate immunohistochemical profiling are valuable for accurate diagnosis and differentiation of ABC from other malignant cervical lesions.
Keywords: Adenoid basal carcinoma, Adenoid cystic carcinoma, basal squamous cellcarcinoma, case report, Immunohistochemistry
Received: 04 Jun 2025; Accepted: 12 Dec 2025.
Copyright: © 2025 Tan and Lai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Liqin Lai
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