CASE REPORT article
Front. Oncol.
Sec. Cardio-Oncology
Case Report: Immune Checkpoint Inhibitor-Associated Myocarditis in an Esophageal Cancer Patient with Myasthenia Gravis Following Combined Radiotherapy and Immunotherapy
Provisionally accepted
- General Hospital of Northern Theatre Command, Shenyang, China
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Myocarditis associated with immune checkpoint inhibitors is a rare but potentially fatal immune-related adverse event. Esophageal cancer patients with myasthenia gravis, who are recommended to receive radiotherapy combined with immunotherapy, are at risk for ICI-related myocarditis. We report a 69-year-old male esophageal cancer patient with myasthenia gravis who was diagnosed with immune checkpoint inhibitor related myocarditis after receiving radiotherapy combined with immunotherapy. The patient's laboratory test results showed elevated troponin and N-terminal proB-type natriuretic peptide. Electrocardiography revealed arrhythmia and complete left bundle branch block. Despite treatment with methylprednisolone, the patient's condition was severe, and clinical and auxiliary examination symptoms continued to deteriorate, leading to his unfortunate demise. In this case, the adverse event of myocarditis induced by radiotherapy combined with immunotherapy in oncology patients with myasthenia gravis is an area that requires further investigation. Clinicians must carefully weigh the potential benefits and risks when considering this combined treatment approach and closely monitor patients for adverse events.
Keywords: case report, esophagealcancer, Immune checkpoint inhibitors (ICIs), Immunotherapy, Radiotherapy
Received: 27 Jun 2025; Accepted: 08 Dec 2025.
Copyright: © 2025 Ren, Yang, Xu and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xue Ren
Ying Yan
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