ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
This article is part of the Research TopicAdvancing Cancer Imaging Technologies: Bridging the Gap from Research to Clinical Practice Volume IIView all 16 articles
"Application of IVIM in assessment of spleen in patients with myelofibrosis"
Provisionally accepted
- 1Uniwersytet Medyczny im Piastow Slaskich we Wroclawiu Katedra Radiologii, Wrocław, Poland
- 2Uniwersytet Mikolaja Kopernika w Toruniu Collegium Medicum im Ludwika Rydygiera w Bydgoszczy, Bydgoszcz, Poland
- 3Specialist Hospital in Legnica, Legnica, Poland
- 4Technische Universiteit Eindhoven epartment of Mathematics and Computer Science, Eindhoven, Netherlands
- 5Politechnika Wroclawska Wydzial Matematyki, Wrocław, Poland
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Aim The purpose of this study is to investigate whether IVIM-derived spleen parameters including the true diffusion coefficient (D) and perfusion fraction (f) can serve as non-invasive biomarkers to predict fibrotic transformation of the bone marrow. Methods Eighteen patients with MPN and 18 healthy controls (HC) underwent abdominal IVIM diffusion-weighted imaging using 1.5 T MR unit. The values of spleen parameters of D and f were compared between patients with various forms of MPN, including 8 patients with myelofibrosis (MF), 10 patients without myelofibrosis (non-MF) and (HC). A Bayesian approach was adopted in the analysis, to assess whether the D and f coefficients, along with the spleen volume, can predict disease occurrence Results Comparing MF patients to HC, Bayesian analysis provided strong evidence for a difference in the f parameter (BF = 18.38), while the difference between MF and non-MF patients was weaker (BF = 1.42). There was no statistically significant difference between non-MF and HC (BF =0. 64). There was no correlation between f parameter and spleen volume (CI= -0,43 ; 0,38). Logistic regression analysis with logkit function confirmed that f parameter was significant predictor of MF. Conclusions The study demonstrates that IVIM measurements of spleen perfusion in both healthy individuals and MPN patients offer valuable predictive information regarding disease development and progression. The f parameter shows promise for predicting fibrotic transformation of the bone marrow in MPN patients regardless of the size of the spleen.
Keywords: IVIM, myelofibrosis, Myeloproliferative neoplasms, Non-invasive diagnostics, Spleen, Spleen volume
Received: 23 Jun 2025; Accepted: 17 Dec 2025.
Copyright: © 2025 Bilski, Sobas, Pawluś, Skarupski and Zimny. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mateusz Bilski
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