ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Genetics
The NSUN5 gene rs1880948 A>G polymorphism and neuroblastoma risk in Chinese children
Provisionally accepted
- Department of Pediatric Surgery，Guangzhou Women and Children's Medical Center, Guangzhou Medical University，Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, Guangzhou, China
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Background:Neuroblastoma (NB) is the most common extracranial solid tumor in children. The 5-methylcytosine (m5C) modification gene NSUN5 polymorphisms may serve as promising molecular markers for identifying populations susceptible to NB. Method:TaqMan probes were used to genotype NSUN5 single nucleotide polymorphisms (SNPs) in 402 NB patients and 473 healthy controls. A logistic regression model was applied to calculate the odds ratio (OR) and 95% confidence interval (CI) to evaluate the association between genotype polymorphisms and NB susceptibility. The analysis was further stratified by age, gender, tumor origin site, and clinical stage. Conclusion :In summary, our study indicates that the selected NSUN5 rs1880948 A>G polymorphisms may not be associated with neuroblastoma susceptibility. However, further studies with larger sample sizes and additional potentially functional polymorphisms are needed to validate these results.
Keywords: Cancer, Neuroblastoma, NSUN5, SNP, 5-methylcytosine Modification
Received: 01 Jul 2025; Accepted: 03 Dec 2025.
Copyright: © 2025 Ye, Zeng, Zheng, Hu, Pan, Yang, Tan, He, Zou and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jing He
Yan Zou
Tianyou Yang
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