REVIEW article
Front. Oncol.
Sec. Cancer Cell Signaling
Ferroptosis: A New Dawn in the Treatment of Acute Lymphoblastic Leukemia
Provisionally accepted
- 1School of Medicine, Shaoxing University, Shaoxing, China
- 2Department of Hematology, Shaoxing People’s Hospital, the First Hospital of Shaoxing University, Shaoxing, China
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Acute lymphoblastic leukemia poses substantial challenges in therapeutic management. As a novel form of programmed cell death, ferroptosis has emerged as a promising research direction in cancer therapy. Studies have emphasized the pivotal role of ferroptosis in ALL, indicating that targeting this pathway could provide a novel therapeutic strategy. This article systematically reviews the molecular regulatory mechanisms of ferroptosis in ALL and explores its potential clinical applications in the treatment and prognostic evaluation of the disease.
Keywords: ferroptosis, Acute Lymphoblastic Leukemia, molecular mechanism, ferroptosis-inducing drugs, Ferroptosis-related genes
Received: 21 Jul 2025; Accepted: 16 Dec 2025.
Copyright: © 2025 Han, 杨, Wei, Jin and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Weiying Feng
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