REVIEW article
Front. Oncol.
Sec. Thoracic Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1675772
This article is part of the Research TopicReviews in Thoracic OncologyView all 4 articles
The impact of heart dose on cardiac injury and survival in lung cancer patients after radiotherapy
Provisionally accepted
- Southeast University, Nanjing, China
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Thoracic radiotherapy is a primary treatment modality for lung cancer, with approximately two-thirds of patients receiving it.The association between heart dose and post-radiotherapy survival and cardiac injury represents a critical area of contemporary radiotherapy research, yet understanding of radiation-induced heart disease (RIHD) in lung cancer remains incomplete.This review synthesizes literature on the effects of heart dose on survival and substructure-specific cardiac injury in lung cancer patients, evaluating thresholds for reversible and irreversible damage to cardiac substructures. We further summarize key mechanisms underlying RIHD.
Keywords: lung cancer, Radiotherapy, heart irradiation dose, Survival, RIHD
Received: 29 Jul 2025; Accepted: 02 Sep 2025.
Copyright: © 2025 Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bingchen Li, Southeast University, Nanjing, China
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