CASE REPORT article
Front. Oncol.
Sec. Gynecological Oncology
This article is part of the Research TopicAdvances in Diagnosis and Treatment of Endometrial CancerView all 22 articles
Corded and hyalinized endometrioid carcinoma:a case report and literature review
Provisionally accepted
- The Second Afffliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Corded and hyalinized endometrioid carcinoma (CHEC) is a rare morphological subtype of endometrioid carcinoma (EC), characterized by a biphasic pattern consisting of epithelial or spindled tumor cells embedded within hyalinized stroma, merging with conventional low-grade EC. We present a case of CHEC in a 24-year-old woman who presented with irregular vaginal bleeding. Imaging showed a mass protruding toward the cervix, and subsequent tumor resection confirmed the diagnosis of CHEC. Immunohistochemical staining for β-catenin and CTNNB1 gene mutation analysis were helpful in the diagnosis of CHEC, and molecular subtyping provided valuable prognostic information to a certain extent. Postoperatively, the patient received progestin therapy for 6 months and remained recurrence-free. Given the rarity of CHEC, distinguishing this disease from other biphasic uterine tumors is crucial. This report aims to enhance recognition of this rare entity, facilitating its accurate diagnosis and preventing inappropriate therapeutic interventions.
Keywords: Corded and hyalinized, CTNNB1, Endometrioid carcinoma, Molecular classification, β-catenin
Received: 31 Jul 2025; Accepted: 18 Dec 2025.
Copyright: © 2025 Liu, Wang, Shi, Wang and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiangong Hu
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.