CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Mixed Adenoneuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of the Literature
Provisionally accepted
- 1Yangzhou University Medical College, Yangzhou, China
- 2Northern Jiangsu People's Hospital, Yangzhou, China
- 3Hunan Normal University School of Medicine, Changsha, China
- 4Department of Pathology and Pathophysiology, Changsha, China
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Neuroendocrine carcinoma (NEC) is a rare malignant tumor of the gallbladder (GB) and is extremely rare in medical practice. Related case reports and in-depth studies are extremely limited, resulting in insufficient understanding of the disease. This article reports a case of a 60-year-old female patient who complained of right upper abdominal pain for 20 days. Subsequent examinations confirmed that it was mixed adenoneuroendocrine carcinoma (GB-MANEC), of which the neuroendocrine part accounted for about 70%, and was defined as a poorly differentiated NEC. The Ki-67 index reached 80%, indicating highly aggressive behavior. Postoperative adjuvant chemotherapy was administered (6 cycles of etoposide combined with cisplatin). Follow-up through December 2024 showed no signs of tumor recurrence, with a disease-free survival period of 12 months.Currently, the preferred treatment strategy for GB-NEC is radical surgery. Therefore, in this case, radical resection combined with chemotherapy became an effective treatment.
Keywords: Gallbladder, mixed adenoneuroendocrine carcinoma, MANEC, neuroendocrine carcinoma, rare malignant tumor, GB-NEC
Received: 27 Aug 2025; Accepted: 31 Oct 2025.
Copyright: © 2025 Du, Yang and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
jiangnan Yang, yjn980114@163.com
Deyuan Fu, 790774128@qq.com
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