BRIEF RESEARCH REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
Divergent Evolution in Bilateral Prostate Cancer: A Case Study
Provisionally accepted
Roni Haas*
Rong Rong HuangAdam WeinerYash PatelLydia Y Liu
Takafumi N Yamaguchi
Raag Agrawal
Paul C. Boutros*
Robert E Reiter*- University of California Los Angeles, Los Angeles, United States
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Abstract Multifocal prostate cancer is a prevalent phenomenon, with most cases remaining uncharacterized from a genomic perspective. A patient presented with bilateral prostate cancer. On systematic biopsy, two indistinguishable clinicopathologic lesions were detected. Whole-genome sequencing displayed somatically unrelated tumours with distinct driver CNA regions, suggesting independent origins of the two tumours. We demonstrated that similar clinicopathologic multifocal tumours, which might be interpreted as clonal disease, can in fact represent independent cancers. Genetic prognostics can prevent mischaracterization of multifocal disease to enable optimal patient management.
Keywords: Clonal disease, driver CNA regions, Multifocal prostate cancer, precision oncology, WGS characterization
Received: 06 Aug 2025; Accepted: 09 Dec 2025.
Copyright: © 2025 Haas, Huang, Weiner, Patel, Liu, Yamaguchi, Agrawal, Boutros and Reiter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Roni Haas
Paul C. Boutros
Robert E Reiter
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