CASE REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
Extra-pancreatic solid pseudopapillary neoplasm: a case report of primary testis origin and review of the literature
Provisionally accepted
- Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, China
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Solid pseudopapillary neoplasm (SPN) is a rare tumor with low malignant potential, generally occurring in the pancreas. In this article, we report a case of extra-pancreatic solid pseudopapillary neoplasm of the testis (ESPN-T) of a 36-year-old male. The patient incidentally discovered a scrotal mass. Ultrasonography revealed a well-defined, regular cystic-solid lesion within the left testis. Magnetic resonance imaging (MRI) showed a nodular mass within the left testis, characterized by an isointense signal on T1-weighted imaging, a heterogeneous signal on T2-weighted imaging, and inhomogeneous enhancement after contrast administration. The patient subsequently underwent radical orchiectomy on the left side. Morphologic and immunohistochemical features of the testicular lesion confirmed the diagnosis of ESPN. Follow-up for 2 years after surgery revealed no signs of recurrence or metastasis. This is a rare case of SPN in the testis in China, which expands the differential diagnosis of testicular lesions and therapeutic strategies of ESPNs.
Keywords: case report, extra-pancreatic solid pseudopapillary neoplasm, Testicular mass, Testis, β-catenin
Received: 23 Aug 2025; Accepted: 15 Dec 2025.
Copyright: © 2025 Lu, Yang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shiyan Li
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