CASE REPORT article
Front. Oncol.
Sec. Hematologic Malignancies
A Case of Cervical Burkitt Lymphoma and Literature Review
Provisionally accepted
- 1Affiliated Hospital of Jining Medical University, Jining, China
- 2Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China
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Abstract Primary cervical Burkitt's lymphoma (BL) is an extremely rare malignancy. This report describes the case of a 55-year-old woman admitted to the hospital with irregular vaginal bleeding. Histologically, the tumor cells demonstrated infiltrative growth, relatively uniform basophilic cytoplasm. Immunohistochemical analysis revealed positivity for B-cell markers (CD20, CD79α, etc.), with MYC expression in approximately 80% of cells, fluorescence in situ hybridization staining showed positivity for MYC translocation and molecular testing confirmed IG rearrangement. The diagnosis of Burkitt's lymphoma is based on its distinctive histological morphology in combination with immunohistochemistry and molecular testing.
Keywords: Burkitt's lymphoma, chemotherapy, EBER, MYC, prognosis
Received: 31 Aug 2025; Accepted: 10 Dec 2025.
Copyright: © 2025 Miao, Bai and Hao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hua Hao
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