CASE REPORT article
Front. Oncol.
Sec. Surgical Oncology
Laryngeal Neurofibroma: Case Report and Review of the Literature
Provisionally accepted
- Sichuan University West China Hospital Department of Otolaryngology Head and Neck Surgery, Chengdu, China
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Background: Laryngeal neurofibromatosis (LNF) represents an exceedingly rare manifestation of neurofibromatosis type 1 (NF1), a genetic disorder affecting neural tissue development with an incidence of approximately 1:3000 live births. While NF1 typically presents with cutaneous neurofibromas, laryngeal involvement is exceptional. Methods: A case of LNF associated with NF1 diagnosed at West China Hospital is presented, accompanied by a comprehensive literature review. A 21-year-old female presented with progressive hoarseness over two years. Diagnostic evaluation included physical examination revealing café-au-lait macules and laryngeal submucosal swelling, and computed tomography (CT) identifying a hypodense parapharyngeal space nodule. The patient underwent microlaryngoscopic excision of the mass. Histopathological examination and genetic analysis were performed. Results: Histopathology confirmed the mass as a neurofibroma. Genetic analysis identified a pathogenic NF1 gene mutation. Microlaryngoscopic excision was successful, achieving complete removal with minimal intraoperative bleeding and no vocal cord damage, resulting in a favorable postoperative outcome. Conclusions: This case details the successful diagnosis and management of rare laryngeal neurofibromatosis, confirming microlaryngoscopic excision as an effective approach. The integrated literature review synthesizes current understanding of this rare entity.
Keywords: case report and literature review, genetic test, Laryngeal neurofibromatosis, microlaryngoscopic excision, NF1
Received: 01 Oct 2025; Accepted: 15 Dec 2025.
Copyright: © 2025 Gao, Mo, Zhu, Zhang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hui Yang
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