ORIGINAL RESEARCH article
Front. Oncol.
Sec. Molecular and Cellular Oncology
BAG3 in human tumors
Provisionally accepted
Paola Manzo1
Anna Lisa Cammarota1
Jelena Dimitrov1
Alessandra Rosati1
Liberato Marzullo1
Maria Caterina Turco1
Vincenzo De Laurenzi2
Gianluca Sala2
Margot De Marco1*
Anna Basile3- 1Universita degli Studi di Salerno Dipartimento di Medicina Chirurgia e Odontoiatria Scuola Medica Salernitana, Baronissi, Italy
- 2Universita degli Studi Gabriele d'Annunzio Chieti Pescara Dipartimento di Tecnologie Innovative in Medicina & Odontoiatria, Chieti, Italy
- 3Universita degli Studi di Salerno, Fisciano, Italy
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Previous studies identified BAG3 as a stress-induced protein with pro-survival functions in various tumors. Based on this assumption, we analyzed the expression and secretion of BAG3 in 24 cancer cell lines representing ten types of cancer and compared these results with samples from primary tumors. BAG3 was ubiquitously expressed and secreted by all cell lines. Serum levels of BAG3 were significantly elevated in patients with liver, pancreatic, and ovarian cancers versus healthy controls. Immunohistochemical analysis confirmed widespread high BAG3 expression across multiple tumor types, often correlating with tumor grade. These data support BAG3 as a key regulator of tumor survival and a promising biomarker and therapeutic target.
Keywords: BAG31, Tumor2, cancer cell lines3, Human serum4, biomarker5
Received: 15 Oct 2025; Accepted: 31 Oct 2025.
Copyright: © 2025 Manzo, Cammarota, Dimitrov, Rosati, Marzullo, Turco, De Laurenzi, Sala, De Marco and Basile. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Margot De Marco, mdemarco@unisa.it
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