Your new experience awaits. Try the new design now and help us make it even better

ORIGINAL RESEARCH article

Front. Oncol.

Sec. Cancer Imaging and Image-directed Interventions

Residual-SwishNet: A Deep Learning-Based Approach for Reliable Lung Cancer Classification

Provisionally accepted
  • 1University of Engineering and Technology, Taxila, Taxila, Pakistan
  • 2Imam Muhammad Ibn Saud Islamic University, Riyadh, Saudi Arabia

The final, formatted version of the article will be published soon.

Lung cancer remains one of the primary causes of cancer-related deaths globally, emphasizing the urgent need for accurate and early diagnosis to improve patient outcomes. However, existing computer-aided detection systems often struggle with suboptimal feature extraction, low classification accuracy, and limited generalizability across datasets. To address these challenges, we propose a deep learning approach named Residual-SwishNet, explicitly designed for the lung cancer classification task. More specifically, we modified the ResNet50 framework by replacing the conventional ReLU activation function with Swish during the feature engineering phase. Further, we integrate three additional dense layers before the classification module to obtain an enriched feature representation. Lastly, we employ a Softmax output layer with Cross-Entropy Loss to tackle the class-imbalance issue. The approach was rigorously evaluated on 2 publicly accessible datasets, named LUNA16 and IQ-OTH/NCCD, using precision, recall, F1-score, and accuracy as performance metrics. Experimental results demonstrate the superiority of our technique, achieving classification accuracies of 99.60% and 99.11% on the LUNA16 and IQ-OTH/NCCD datasets, significantly outperforming existing state-of-the-art techniques. These findings highlight the potential of the proposed model as a robust and reliable tool for lung cancer diagnosis.

Keywords: Classification, deep learning, lung cancer, Resnet50, SWISH

Received: 01 Nov 2025; Accepted: 18 Dec 2025.

Copyright: © 2025 Nawaz, Javed and Saudagar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Ali Javed
Abdul Khader Jilani Saudagar

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.