ORIGINAL RESEARCH article
Front. Oncol.
Sec. Genitourinary Oncology
This article is part of the Research TopicMolecular Imaging Guided Diagnosis and Treatment in OncologyView all articles
Glomerular Filtration Rate In patients with Renal Space-occupying masses Using Combination of SPECT 99mTc-DTPA renal dynamic imaging and Contrast-Enhanced CT
Provisionally accepted
- 1Department of Nuclear Medicine, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
- 2Department of Medical Equipment, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China
- 3Medical Imaging Center, Tai'an City Central Hospital, Tai’an, China
- 4School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China
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Objective: To investigate changes in Glomerular Filtration Rate (GFR) and influencing factors in patients with renal space-occupying masses using a combination of single-photon emission computed tomography (SPECT) Tc-99m-labeled diethylenetriaminepentacetic acid (99mTc-DTPA) renal dynamic imaging and contrast-enhanced computed tomography (CT). Methods: Fifty patients with renal masses underwent SPECT 99mTc-DTPA renal dynamic imaging and contrast-enhanced CT scans, and the GFR of the diseased kidney was compared with that of the contralateral healthy kidney in the same patient. The correlation between the size of the masses and the reduction in GFR was analyzed. Besides, the relationships between the net increment CT values in the renal parenchymal phase and excretory phase with the GFR changes were analyzed. Results: The GFR of diseased kidneys was significantly lower than that of the healthy kidneys (p<0.05). There was no correlation between the size of the masses and the reduction in GFR (r=0.23, p>0.05). A negative correlation was found between the net increment CT value in the parenchymal phase and the decline in GFR (r=-0.38, p<0.05), while there was no correlation between the net increment CT value in the excretory phase and the decline in GFR (r=-0.26, p>0.05). Conclusion: The blood supply characteristics observed in contrast-enhanced CT scans of renal masses can influence the calculation of GFR in radionuclide renal dynamic imaging. These characteristics should be taken into account when interpreting GFR results. Keywords: SPECT, Renal dynamic imaging, 99mTc-DTPA, Contrast-Enhanced CT, Glomerular filtration rate (GFR)
Keywords: 99mTc-DTPA, Contrast-enhanced CT, Glomerularfiltration rate (GFR), Renal dynamic imaging, SPECT
Received: 01 Nov 2025; Accepted: 17 Dec 2025.
Copyright: © 2025 Jia, Jiang, Li, Nie and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Baojian Wang
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