ORIGINAL RESEARCH article
Front. Oncol.
Sec. Hematologic Malignancies
Perspective Recommendations on Geriatric Support for Older Adults with Multiple Myeloma Based on Challenges Faced by A Multidisciplinary Team
Julie Côté 1
Ploa Desforges 2
Christine Dionne 3
Frédéric Larose 4
Erika Martinez 5
Sabrina Trudel 6
Drena Walker 7
1. Centre Hospitalier Universitaire de Québec, Québec, Canada
2. McGill University, Montreal, Canada
3. Centre intégré universitaire de santé et de services sociaux (CIUSSS) de la Capitale-Nationale, Quebec, Canada
4. Université de Laval, Laval, Canada
5. Centre Intégré Universitaire de Santé et de Services Sociaux (CIUSSS) du Centre-Ouest-de l'Île-de Montréal, Montreal, Canada
6. Hôpital Charles-Le Moyne, Greenfield Park, Canada
7. McGill University Health Center, Montreal, Canada
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Abstract
Background: Multiple Myeloma (MM) predominantly affects older adults, with a median diagnosis age of 70 years, posing challenges in management due to frailty, comorbidities, and age-related physiological changes. As the aging population grows, the prevalence of MM in older patients is expected to rise, requiring improved clinical strategies. Methods: This consensus report outlines a multidisciplinary framework for the identification, geriatric assessment (GA), and management of older adults with MM, emphasizing the role of frailty assessments, such as the IMWG frailty score, in tailoring treatments. The objective is to develop a working model tailored to the Quebec context. A meeting on May 7, 2024 brought together experts to discuss improving access to GA and developing strategies for implementing geriatric management tools. Unmet needs include the lack of standardized screening tools, limited access to specialized geriatric oncology services, and inconsistent treatment approaches. Personalized care is critical in addressing frailty, comorbidities, patient preference, and functional status. Results: This report proposes a structured referral pathway involving age-based triaging and criteria for geriatric consultation. Multidisciplinary teams, including geriatricians, are essential for optimizing care and improving outcomes, with a focus on quality of life and effective therapies. Standardized practices and collaborative approaches are vital for addressing the complexities of MM in this vulnerable population.
Summary
Keywords
adverse events, bispecific antibodies, CAR T-cells, Geriatric patients, Multiple Myeloma, referral pathway, T-cell–redirecting therapy
Received
20 May 2025
Accepted
17 February 2026
Copyright
© 2026 Côté, Desforges, Dionne, Larose, Martinez, Trudel and Walker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Julie Côté
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