ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gynecological Oncology
Mechanism of N6-methyladenosine (m6A)-mediated upregulation of LINC00958 in the growth of cervical cancer
Provisionally accepted
- Southern Central Hospital of Yunnan Province, Honghe, China
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Objective: Cervical cancer (CC) remains a prominent contributor to cancer mortality amongst women. Long non-coding RNAs (LncRNAs) participate in CC progression. This study probed into the potential mechanism of LINC00958 in CC growth. Materials and Methods: LINC00958 expression in CC tissues and cells was determined. The correlation between LINC00958 expression and CC prognosis was analyzed. LINC00958 expression was interfered in CC cells, followed by assessment of CC cell proliferation and apoptosis. An xenograft tumor model was established in nude mice. METTL3, c-MYC, and BAG3 expression was determined. m6A level was quantitatively analyzed, and the level of m6A-modified LINC00958 was detected. The binding of LINC00958 to c-MYC, as well as the binding of c-MYC to BAG3 were confirmed. Functional rescue experiments were designed to verify the effect of METTL3/BAG3 on CC growth. Results: LINC00958 expression was elevated in CC and correlated with the prognosis and clinicopathological features of CC patients. LINC00958 silencing suppressed CC cell proliferation and facilitated apoptosis in vitro, and repressed tumor growth in vivo. Mechanically, METTL3-mediated m6A modification elevated LINC00958 expression by promoting LINC00958 stability. LINC00958 activated the transcriptional activity of c-MYC, and c-MYC bound to BAG3. METTL3 overexpression or BAG3 overexpression offset the impact of LINC00958 silencing on CC growth. Conclusion: METTL3-mediated m6A modification elevated LINC00958 expression. LINC00958 enhanced CC cell proliferation but depressed apoptosis via the c-MYC/BAG3 axis.
Keywords: BAG3, cervical cancer, c-Myc, LINC00958, m6A modification, METTL3
Received: 11 Jul 2025; Accepted: 03 Feb 2026.
Copyright: © 2026 Li, Liu and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuting Li
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