SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Gynecological Oncology
Clinical diagnosis and treatment of uterine teratomas: a systematic review
Provisionally accepted
- 1The First Hospital of Jilin University, Changchun, China
- 2Jilin Women and Children Hospital, Changchun, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Purpose: Uterine teratoma, a rare tumor of the female reproductive system, poses diagnostic challenges. We report a case of mature teratoma in the endometrium and conduct a systematic review to analyze clinical characteristics, diagnosis, treatment, and prognosis. Methods: We systematically searched English literature on uterine teratomas from inception to October 5, 2025, using the modified Newcastle Ottawa Scale for quality assessment. The OSF registration number is https://doi.org/10.17605/OSF.IO/H75KV. Results: Our review included 39 papers (40 cases). Mature teratomas (25 cases) were more common than immature teratomas (15 cases). Mean age at diagnosis was 38.8 ± 15.6 years, with a mean teratoma size of 6.3 ± 4.9 cm. Endometrial teratomas often present with irregular vaginal bleeding or abnormal secretions, and hysteroscopy could aid in pre-operative diagnosis. Most mature teratomas were managed with tumor resection, resulting in good prognosis and minimal recurrence. Immature teratoma treatment remains controversial. Uterine teratoma should be considered in women with vaginal bleeding or abnormal secretions, and heterogeneous uterine masses. Conclusions: Hysteroscopy, along with CT and MRI, can improve pre-operative diagnosis. Treatment plans should be individualized based on age, fertility needs, tumor location, nature, risk factors, and progression.
Keywords: clinical diagnosis, Dermoid Cyst, immature, Treatment, Uterine teratomas
Received: 17 Oct 2025; Accepted: 05 Jan 2026.
Copyright: © 2026 Shen, Zhang, Chen and Shao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wen-Jing Shao
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.