CASE REPORT article
Front. Oncol.
Sec. Radiation Oncology
This article is part of the Research TopicCase Reports in Radiation Oncology: 2025View all 32 articles
Primary Extranodal Marginal Zone Non-Hodgkin Lymphoma of the Prostate: A Case Report
Provisionally accepted
- 1Gansu University of Traditional Chinese Medicine, lanzhou city, China
- 2Gansu Provincial People's Hospital Department of Radiotherapy I, Lanzhou, China
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This report describes a clinically rare case of early-stage primary extranodal marginal zone B-cell lymphoma of the prostate. A 73-year-old male presented with urinary hesitancy. Physical examination revealed mild prostatic enlargement. Prostate biopsy, immunohistochemistry, and genetic testing strongly suggested mucosa-associated lymphoid tissue (MALT) lymphoma. Bone marrow aspiration indicated no bone marrow involvement. Positron Emission Tomography-Computed Tomography (PET-CT) and Emission Computed Tomography (ECT) scans showed no evidence of involvement in other sites. Ultimately, the patient was definitively diagnosed with primary prostatic MALT lymphoma, Ann Arbor stage IE. He underwent external beam radiation therapy to the prostate, receiving a total dose of 3000 cGy delivered in 15 fractions. During radiotherapy, the patient experienced no significant adverse reactions. Following treatment, urinary obstruction symptoms markedly improved. Follow-up abdominal and urinary tract ultrasound examinations at 1 week, 1 month, and 4 months post-radiotherapy showed marked tumor regression with no signs of recurrence. This report aims to share the treatment experience of this case, hoping to provide insights for clinicians.
Keywords: case report, extra-nodal marginal zone-B lymphoma, non-Hodgkin lymphoma, Prostate, radiation therapy
Received: 09 Oct 2025; Accepted: 10 Feb 2026.
Copyright: © 2026 Gao, Wang, WANG and Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hongyi Cai
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