ORIGINAL RESEARCH article
Front. Oncol.
Sec. Breast Cancer
Impact of Contrast-Enhanced Ultrasound Optimized Breast Imaging Reporting and Data System Category on the Biopsy Decision for Non-Mass Breast Lesions
Provisionally accepted
Xuexue Chen1
Mengyuan Fang2
Huajie Pei1
Lingling LI1Bing Zhang1
Haimei Lun1Liu Wei1Bing Ling1Yingying He1
Qiao Hu1*- 1People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China
- 2Changsha Hospital for Maternal & Child Health Care, Changsha, China
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Objective: To investigate the impact of contrast-enhanced ultrasound (CEUS) optimized Breast Imaging Reporting and Data System (BI-RADS) prediction model on the biopsy decision for non-mass breast lesions (NMLs). Methods: 148 NMLs histopathologically confirmed from 142 patients who underwent ultrasound (US) and CEUS examination were retrospectively enrolled. US and CEUS features were compared between malignant and benign NMLs. A CEUS-optimized BI-RADS category prediction model was developed using logistic regression. The diagnostic performance and impact on biopsy decision of US and CEUS-optimized BI-RADS category were compared. Results: Of 148 NMLs, 77 were malignant and 71 benign. CEUS features such as earlier wash-in, later wash-out, hyperenhancement, heterogeneous enhancement, enlarged enhancement extent, and crab claw-like enhancement were significantly associated with malignancy (P<0.05). The enlarged enhancement extent and crab claw-like enhancement were independent risk factors for malignancy (P<0.05). Using BI-RADS 4B as the cutoff, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for diagnosing NMLs increased from 53.2%, 63.4%, 61.2%, 55.6%, and 58.1% before optimization to 93.5%, 81.7%, 84.7%, 92.1%, and 87.8% after CEUS optimization, respectively. With BI-RADS 4A or 4B as the biopsy threshold, the biopsy rate, malignancy detection rate, and missed diagnosis rate were 100%, 52.03%, and 0% before optimization, changing to 75%, 66.67%, and 3.90% after optimization for 4A, respectively. The corresponding values for 4B were 45.95%, 60.29%, and 46.75% before optimization, and 57.43%, 84.71%, and 6.49% after optimization, respectively. Conclusion: The CEUS-optimized BI-RADS category prediction model could provide valuable guidance for biopsy decision-making in NMLs.
Keywords: Biopsy, Breast Imaging Reporting and Data System category, contrast-enhanced ultrasound, Conventional Ultrasound, Non-mass breast lesions
Received: 24 Oct 2025; Accepted: 03 Feb 2026.
Copyright: © 2026 Chen, Fang, Pei, LI, Zhang, Lun, Wei, Ling, He and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiao Hu
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