ORIGINAL RESEARCH article
Front. Oncol.
Sec. Radiation Oncology
This article is part of the Research TopicRadiation Spatial Fractionation—A novel approach to integrate Physics, Biology, and Immunology for high therapeutic index radiotherapyView all 15 articles
Respiratory Motion Effects and Plan Robustness for Lattice Radiation Therapy
Provisionally accepted
- The University of Texas MD Anderson Cancer Center, Houston, United States
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Introduction: Lattice radiation therapy (LRT), a form of spatially fractionated radiation therapy (SFRT), has shown promise in treating bulky tumors. It consists of hot and cold spots within the tumor and the ratio between these doses is thought to be important in clinical outcomes. Respiratory motion is expected to degrade these peak-to-valley dose ratios (PVDR) but has largely been ignored in LRT literature and clinical practice. This work aims to quantify the response of LRT dose distributions to motion to better inform motion management decisions and improve clinical outcomes. Methods: Respiratory motion of peak-to-peak amplitudes from 0.3 to 2 cm was simulated in 1 and 1.5 cm sphere lattice plans in a uniform phantom using dose perturbations. A similar analysis was repeated with retrospective patient plans to understand the effect of anatomical variation in motion response. Finally, deformed and rigid dose transformations were compared to understand the effect of tumor deformation on motion response. Results: Hot spheres (VTVH) lost coverage with increasing motion, while cold spheres (VTVL) experienced either an increase (anterior-posterior motion) or decrease (superior-inferior motion). The ratio of the two (VTVH/VTVL D95%) decreased with increasing motion. Patient data results generally agreed with phantom results. 1.5 cm sphere plans were less sensitive to motion than 1 cm sphere plans with statistical differences between the two responses. Mean (standard deviation) percent changes from no motion to 1 cm superior-inferior motion for patient plans are as follows with phantom values listed after: VTVH D80% change was -13.8 (1.2), -12.7 for 1.5 cm spheres and -15.8 (1.8), -13.8 for 1 cm spheres; and VTVH/VTVL D95% change was -7.1 (4.0), -15.0 and -13.0 (3.5), -12.0, respectively. Generally, no significant difference was observed between deformed and perturbed dose distributions. Discussion: Large tumor motion can degrade LRT dose distributions which could lead to less effective treatments. Suggested cutoffs of 1 cm motion for 1.5 cm sphere plans and 0.5 cm motion for 1 cm sphere plans are proposed above which motion limiting strategies should be applied. Caution should be applied for tumors with large deformations as these may change the dose distributions in unexpected ways.
Keywords: lattice therapy, Liver, motion management, radiation therapy, Respiratory motion, SFRT
Received: 24 Oct 2025; Accepted: 03 Feb 2026.
Copyright: © 2026 Martin-Paulpeter, Balter, Perles, Ludmir and Niedzielski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Rachael M Martin-Paulpeter
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.