CASE REPORT article
Front. Oncol.
Sec. Cardio-Oncology
Case report: Surgical resection combined with chemotherapy for a primary cardiac lymphoma involving right heart structures
Provisionally accepted
- The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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Primary cardiac lymphoma is a highly rare type of malignant tumor that originates from the lymphoid tissue within the heart or pericardium. Surgical treatment is the primary method for obtaining pathological results and relieving obstructions, and chemotherapy is the main method for disease control. We present a case of a 67-year-old woman diagnosed with primary cardiac lymphoma, presenting with shortness of breath and bilateral lower extremity edema after activity. Multimodality imaging results suggest a primary cardiac lymphoma, which was located in the right atrioventricular groove. Surgical resection of the mass was performed and histopathology confirmed the diagnosis of primary cardiac lymphoma. Based on the genetic results, Pola-R-CHP was used for postoperative chemotherapy. Fortunately, no evidence of recurrence of primary cardiac lymphoma was showed 8 months after surgery. Surgical resection combined with chemotherapy has achieved satisfactory results in the treatment of primary cardiac lymphoma.
Keywords: chemotherapy, histopathology, multimodality imaging, primary cardiac lymphoma, surgical treatment
Received: 27 Oct 2025; Accepted: 30 Jan 2026.
Copyright: © 2026 Zhu, Ren, Xiong, Chen, Huang, Peng, Lin and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoping Fan
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