CASE REPORT article
Front. Oncol.
Sec. Pediatric Oncology
This article is part of the Research TopicCase Reports in Pediatric Oncology: 2025View all 12 articles
Chemotherapy Management of a Pediatric B-ALL Patient with Moyamoya Disease: a case report
Provisionally accepted
- Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Moyamoya disease is a rare, chronic cerebrovascular disorder characterized by progressive stenosis or occlusion of the terminal portions of the internal carotid arteries and the subsequent development of abnormal compensatory vascular networks. It represents a significant cause of intracranial arteriopathy and is a major etiology of stroke and transient ischemic attack in pediatric populations. We present the case of a 9-year-old boy with confirmed diagnosis of B-cell acute lymphoblastic leukemia (B-ALL), in whom brain MRI findings were suggestive of Moyamoya disease. This report underscores the rarity of the co-occurrence of B-ALL and Moyamoya disease and highlights the importance of early recognition and timely intervention during chemotherapy to reduce the risk of neurological complications. Our findings may offer valuable insights for the chemotherapeutic management of ALL patients with coexisting Moyamoya disease.
Keywords: antithrombotic strategies5, B-cell acute lymphoblastic leukemia1, chemotherapymanagement3, Moyamoya disease2, Neurological Complications4
Received: 27 Oct 2025; Accepted: 03 Feb 2026.
Copyright: © 2026 Cheng, Zhou, Han and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fen Zhou
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