ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
This article is part of the Research TopicArtificial Intelligence in Immunotherapy for Gastrointestinal Cancers: From Prediction to Precision MedicineView all 7 articles
SpectraNet: A Novel Model for Polyp Segmentation Leveraging a Spectral-Guided Mixture of Functional Experts
Provisionally accepted- Jiangyan Hospital Affiliated to Nanjing University of Chinese Medicine, Taizhou, China
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Automated and precise polyp segmentation from colonoscopy images is critical for the early diagnosis of colorectal cancer. However, this task is challenged by the ambiguous and low-contrast boundaries of polyps, which often blend with the surrounding mucosa. To address this, we propose SpectraNet, a novel hybrid-domain enhancement network for high-precision polyp segmentation. Our model is built on an encoder-decoder architecture with two core innovations integrated into its skip connections: (1) a Spectral-Guided Boundary Enhancement (SGBE) module that operates in the frequency domain to recover and sharpen indistinct boundary information by enhancing the phase spectrum of features, and (2) a Function-Specialized Mixture-of-Experts (FS-MoE) module that adaptively refines features for diverse polyp morphologies using a set of heterogeneous, function-specific experts. Extensive experiments on our curated PolypSegDataset and two public benchmarks (Kvasir-SEG and CVC-ClinicDB) demonstrate that our method consistently outperforms a wide range of state-of-the-art models. SpectraNet achieves superior performance in key segmentation metrics, and produces qualitatively more accurate segmentation masks with precise boundary definitions.
Keywords: deep learning, Foundation model, Frequency domain enhancement, Mixture of experts, polyp segmentation
Received: 28 Oct 2025; Accepted: 26 Jan 2026.
Copyright: © 2026 Liu and Ling. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jing Ling
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