CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
A case report : Gastric glomus tumor with RAD50 mutation and therapeutic advances
Di Zhang 1,2
Wei Zhang 2
Lun Zhang 1,2
Jing Chen 1,2
Zhiliang Jin 2
1. Yangtze University Medical School, Jingzhou, China
2. Yangtze University Jingzhou Hospital, Jingzhou, China
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Abstract
Gastric glomus tumor (GGT) is a rare mesenchymal neoplasm of the stomach that accounts for only 1% of gastrointestinal tumors and originates from glomus cells within the gastric wall. The exact etiology remains unclear, and due to nonspecific clinical manifestations, definitive diagnosis relies on imaging, pathology, and immunohistochemistry. We report a case of a 60-year-old female with a two-year history of unexplained upper abdominal burning pain. After undergoing abdominal CT, gastroscopy, pathology, and immunohistochemistry analyses, she was diagnosed with gastric glomus tumor complicated by hepatic metastasis.The patient subsequently received chemotherapy, transcatheter arterial embolization(TAE) for hemostasis, anti-infection treatment, blood transfusion, and symptomatic and supportive care at our hospital. Ultimately, the patient's overall survival was 21 months. This article presents the case and reviews the clinical presentation, pathological features, diagnosis, and treatment strategies for GGT to provide reference for clinical practice.This case report has been reported in line with the CARE guidelines and submit a completed CARE checklist as a supplementary material(Table 1).
Summary
Keywords
case report6, Chemotherapy5, diagnosis2, Gastric glomus tumor1, Genetictest4, immunohistochemistry3
Received
13 November 2025
Accepted
18 February 2026
Copyright
© 2026 Zhang, Zhang, Zhang, Chen and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Zhiliang Jin
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