CASE REPORT article
Front. Oncol.
Sec. Gynecological Oncology
This article is part of the Research TopicArtificial Intelligence in Gynecological Oncology: Advances in Imaging and Therapeutic StrategiesView all articles
Case Report: Rare Vulvar Myofibroblastoma
Provisionally accepted
- 1Zhejiang Chinese Medical University, Hangzhou, China
- 2Obstetrics and Gynecology Hospital in Hangzhou, Hangzhou, China
- 3Hangzhou Normal University, Hangzhou, China
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Vulvar Myofibroblastoma is a rare mesenchymal tissue tumor originating from myofibroblasts, with an unclear pathogenesis and biological behavior considered to be of uncertain malignant potential or low-grade malignancy. To investigate the clinical and pathological features of vulvar myofibroblastoma, a retrospective study was conducted on a rare case of vulvar myofibroblastoma admitted to Hangzhou Obstetrics and Gynecology Hospital. The patient was an elderly woman who presented with vulvar itching for 20 years and found a vulvar mass for 3 days. Following initial examination, she underwent vulvar mass resection. Postoperative pathology suggested a myofibroblastic tumor with biological behavior of uncertain malignant potential or low-grade malignancy. As postoperative imaging evaluation indicated residual tumor, the patient subsequently underwent wide local excision of the vulva, which confirmed the diagnosis of vulvar myofibroblastoma. Short-term follow-up showed good recovery with no signs of recurrence or metastasis. In summary, for the diagnosis of rare vulvar myofibroblastoma, imaging examinations can help determine the tumor's location, size, and relationship with surrounding tissues, but definitive diagnosis relies on histopathology. Treatment should aim for complete resection during the initial surgery. Given the uncertainty of its biological behavior, establishing a strict long-term follow-up mechanism is crucial for monitoring recurrence and ensuring the patient's long-term prognosis.
Keywords: case report, Clinicopathological features, diagnosis andtreatment strategies, surgical management, vulvar myofibroblastoma
Received: 20 Nov 2025; Accepted: 29 Jan 2026.
Copyright: © 2026 Miao, Sheng, Xu, Qian and Nong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shaoqin Sheng
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