REVIEW article
Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Advances in Molecular and Genetic Profiling of Meningiomas for Improved Diagnosis, Prognosis, and Targeted Therapy
Provisionally accepted
- PSG Institute of Medical Sciences & Research, Coimbatore, India
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Background: Meningiomas exhibit substantial biological and clinical heterogeneity, and traditional histopathology alone often fails to accurately predict tumor behavior. Advances in molecular and genetic profiling have significantly enhanced diagnostic precision, prognostic assessment, and therapeutic decision-making. Methods: This review synthesizes current evidence on genomic, epigenomic, transcriptomic, and liquid biopsy–based approaches used to characterize meningiomas. Results: Key developments include characterization of NF2 and non-NF2 driver mutations, refinement of DNA methylation-based classification systems, identification of high-risk markers such as TERT promoter mutations and CDKN2A/B deletions, and the emergence of targeted therapeutic strategies. Liquid biopsy and circulating biomarkers further enable non-invasive disease monitoring and molecular risk stratification. Conclusion: Molecular profiling has transformed meningioma classification and risk prediction, supporting a shift toward precision neuro-oncology. Future progress will depend on integrated multi-omic diagnostics, improved biomarker-guided surveillance, and development of targeted therapeutic options for aggressive molecular subgroups.
Keywords: DNA Methylation, Meningioma, Molecular profiling, Neuro-Oncology, targeted therapy
Received: 20 Nov 2025; Accepted: 09 Feb 2026.
Copyright: © 2026 Kasi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Muthiah Kasi
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