CASE REPORT article
Front. Oncol.
Sec. Hematologic Malignancies
This article is part of the Research TopicCase-based Advances in the Understanding of Rare and Unusual Hematologic Malignancies 2025-2026View all 21 articles
Non-leukemic myeloid sarcomasinvolving only the central nervoussystem:a case report and literaturereview
Provisionally accepted
- 1Hebei Chest Hospital, Shijiazhuang, China
- 2Beijing Chest Hospital Affiliated to Capital Medical University, Beijing, China
- 3Shijiazhuang People's Hospital, Shijiazhuang, China
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Word count: 185 A previously healthy 30-year-old male presented with a five-month history of dizziness and progressive numbness and weakness of the lowerlimbs for more than two months. Contrast-erhanced MRI revealed multiple enhancing soft tissue masses in the spinal canal, while PET/CTindicated numerous hypermetabolic lesions in the intracranial and spinal regions. Inital pathological findings suggested inflammatory lesions, and the diagnosis remained uncertain after consultations at multiple hospitals. The patient was admitted to our hospital on June 15, 2019.Subsequent examinations after admission ruled out tuberculosis infection. A lumbar puncture was performed, and cerebrosoinal fuid wascollected for cytological examination, revealing numerous abnormal cells. We suspected the presence of a tumor. After intrathecalchemotherapy, the patient's symptoms showed some improvement; however, subsequent imaging revealed progression of the intracraniallesions accompanied by cerebral herniation. A repeat surgical biopsy suggested myeloid sarcoma (MS), The patient was transferred to acancer hospital for chemotherapy but succumbed to the critical illness on September 16, 2019. Through this case report, we hope to gain abetter understanding of myeloid sarcoma. Timely diagnosis and appropriate treatment are essential for obtaining the desired results.
Keywords: Central nervous system2, diagnosis4, intrathecal injection5, Leukemia3, myeloid sarcoma1
Received: 17 Dec 2025; Accepted: 16 Feb 2026.
Copyright: © 2026 Han, He, Chen, Zheng and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yanqiang Chen
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