CASE REPORT article
Front. Oncol.
Sec. Pediatric Oncology
Primary Vaginal Yolk Sac Tumor in an 11-Month-Old Girl: A Case Report
JiaCheng YOU 1,2
Wei Xia 2,3
1. Wuhan University of Science and Technology School of Medicine, Wuhan, China
2. Wuhan Women and Children Medical Care Center, Wuhan, China
3. Huazhong University of Science and Technology Tongji Medical College, Wuhan, China
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Abstract
Background: Extragonadal yolk sac tumors are exceedingly rare. This report describes a vaginal yolk sac tumor in an infant to highlight key diagnostic and therapeutic aspects and its inclusion in the differential diagnoses of unexplained vaginal masses. Case presentation: An 11-month-old girl presented with intermittent vaginal bleeding, initially misdiagnosed as a hematoma. Pathological examination confirmed yolk sac tumors. She underwent hysteroscopic resection and six cycles of PEB (bleomycin, etoposide, cisplatin) chemotherapy. No recurrence occurred during the 12-month follow-up. Conclusion: Primary vaginal yolk sac tumors are extremely rare and lack standardized treatment. Surgery combined with PEB chemotherapy proved effective in this case.
Summary
Keywords
case report, Extragonadal, Gynecology, Pediatrics, yolk sac tumor
Received
03 December 2025
Accepted
20 February 2026
Copyright
© 2026 YOU and Xia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Wei Xia
Disclaimer
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