ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gynecological Oncology
Dosimetric Comparison of MRI-guided and CT-guided Intracavitary and Interstitial Brachytherapy for Locally Advanced Cervical Cancer
Wencui Yang
Jun Lu
Li Wang
Haiyun Wang
Peng Li
Xi'an International Medical Center Hospital, Xi’an, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Abstract
Purpose: To compare the differences in dosimetry and toxicities between Magnetic Resonance Imaging (MRI) and Computed Tomography (CT)-guided intracavitary and interstitial implantation for locally advanced cervical cancer, respectively. Methods: We analyzed 40 cases of locally advanced cervical cancer admitted to our hospital from January 2023 to September 2024. Patients underwent CT-guided intracavitary and interstitial implantation followed by MRI scanning. We compared the volume of HR-CTV and IR-CTV, the dosimetric differences of HR-CTV D90 and IR-CTV D90, and the dosimetric differences of D2cc for the bladder, rectum, and small intestine under the two localization methods. Results: The mean HR-CTV and IR-CTV volumes were larger using CT guidance compared with MRI guidance (P<0.05), the differences were statistically significant. The HR-CTV D90 and IR-CTV D90 were smaller using CT than MRI guidance. The difference was statistically significant (P<0.05). There was a statistically significant difference in the rectum D2cc between CT and MRI guidance (P<0.05), while there was no statistically significant difference for the D2cc of the bladder and small intestine between the two methods (P>0.05). Conclusion: Intracavitary and interstitial implantation under MRI guidance can significantly improve HR-CTV and IR-CTV D90 with reduced target volume and good protection of the rectum, and there is no significant difference for the bladder and small intestine.
Summary
Keywords
cervical cancer, Intracavitary and Interstitial Implantation, MRI imaging, Three-dimensional brachytherapy, tumor
Received
11 December 2025
Accepted
17 February 2026
Copyright
© 2026 Yang, Lu, Wang, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Wencui Yang
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.