CASE REPORT article
Front. Oncol.
Sec. Cancer Genetics
A Rare Pulmonary Epithelioid Angiosarcoma with ALK Rearrangement: A case report and literature review
Provisionally accepted
- 1Armed Police Corps Hospital of Hubei Province, Wuhan, China
- 28th Medical Center of Chinese PLA General Hospital, Beijing, China
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Epithelioid angiosarcoma is a rare type of malignant tumor that progresses rapidly and currently lacks standard and effective treatment methods. We present herein the first reported case of rare pulmonary epithelioid angiosarcoma harboring an EML4-ALK fusion, in which targeted therapy demonstrated efficacy. This advanced, unresectable epithelioid angiosarcoma continued to progress despite prior treatments, including chemotherapy, anti-angiogenic therapy, immunotherapy, and radioactive particle implantation. Given the absence of standardized treatment protocols for this malignancy, we performed next-generation sequencing (NGS) to identify potential therapeutic targets, which revealed an ALK fusion. Subsequent ALK-targeted therapy proved effective, providing novel therapeutic insights for patients with advanced, unresectable disease. Further studies are warranted to elucidate the mutational landscape of pulmonary epithelioid angiosarcoma and its implications for disease pathogenesis, progression, treatment response, and prognosis.
Keywords: ALK, Epithelioid angiosarcoma, NGS - next generation sequencing, Pulmanory Disease, Treatmen strategy
Received: 04 Jan 2026; Accepted: 12 Feb 2026.
Copyright: © 2026 Gong, Zheng, Tian, Xiao, Yu, Jiang and Bao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lin Jiang
Pengtao Bao
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