CASE REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
Clear Cell Renal Cell Carcinoma Combined with Intravascular Large B-Cell Lymphoma: a case report and review of the literature
Provisionally accepted
- 1Zhejiang Hospital, Hangzhou, China
- 2The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- 3Jiyuan People's Hospital, Henan, China
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Background: Clear cell renal cell carcinoma (ccRCC) combined with intravascular large B-cell lymphoma (IVLBCL) is an extremely rare collision tumor, and its coexistence is often missed or misdiagnosed, making clinical diagnosis and treatment notably difficult. Case demonstration: We present the case of a 68-year-old male, in whom imaging revealed a nodular soft tissue density shadow in the parenchyma of the left kidney. Immunohistochemistry and molecular testing confirmed the combination of ccRCC and IVLBCL. Following surgery, the patient underwent comprehensive examinations, including bone marrow biopsy and cytology, to rule out systemic lymphoma involving the kidneys. The patient received postoperative chemotherapy and was still in a favorable condition after 16 months of follow-up. Conclusion: In the ccRCC combined with IVLBCL, the lymphoma component is confined within the blood vessels of the RCC, making it extremely prone to misdiagnosis, which can lead to a poor prognosis. This case report presents an incidental finding of ccRCC combined with IVLBCL, aiming to raise physician awareness and provide valuable clinical references.
Keywords: Clear cell renal cell carcinoma, Clinicopathological features, diagnostic, Intravascular large B-cell lymphoma, Renal
Received: 15 Jan 2026; Accepted: 05 Feb 2026.
Copyright: © 2026 Zheng, Shou, Zhou, Liu, Yang, Liu and Jianguo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wei Jianguo
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