CASE REPORT article
Front. Oncol.
Sec. Breast Cancer
This article is part of the Research TopicNovel Anti-Cancer Agents Targeting Triple-Negative Breast CancerView all 7 articles
Efficacy of Sacituzumab govitecan in Triple-Negative Breast Cancer with Hepatic Visceral Crisis: a case report
Provisionally accepted
- 1Quzhou City People's Hospital, Quzhou, China
- 2Jining Medical University, Jining, China
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Triple-negative breast cancer (TNBC) is recognized as the most aggressive molecular subtype of breast cancer (BC). The liver is a common site of distant metastasis in BC, and hepatic involvement is associated with accelerated therapeutic resistance and increased mortality risk. Although sacituzumab govitecan (SG) has shown favorable clinical efficacy in the treatment of BC with liver metastasis in the ASCENT randomized controlled trial and real-world studies, its application value in hepatic visceral crisis (HVC) remains inadequately investigated. Herein, we report the clinical course and outcomes of a TNBC patient with diffuse liver metastasis. Following two cycles of SG treatment, the patient achieved significant remission of liver lesions, with a progression-free survival (PFS) of 16.3 months. This case report highlights the necessity of conducting further in-depth studies to explore the application of SG in BC patients with visceral crisis (VC).
Keywords: Antibody-drug conjugate, hepatic visceral crisis, partial response, Sacituzumab govitecan, Triple-negative breast cancer
Received: 18 Jan 2026; Accepted: 13 Feb 2026.
Copyright: © 2026 Ye, Ye, He, Jiang, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiaqi Ye
Jiaang Ye
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