REVIEW article
Front. Oral Health
Sec. Oral Infections and Microbes
This article is part of the Research TopicThe promising potential of autologous-derived products in oral wound healing and tissue regenerationView all articles
Beyond the Clot: How the Biomolecular Landscape of Platelet-Rich Fibrin Directs Fibroblast Functions
Provisionally accepted
- 1University of British Columbia, Vancouver, Canada
- 2Faculty of Dentistry, Department of Oral Biological Sciences, University of British Columbia, Vancouver, Canada
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Platelet-Rich Fibrin (PRF) is a second-generation autologous blood concentrate widely applied in regenerative medicine and dentistry for its wound-healing potential. Its clinical applications span dermatology, plastic surgery, periodontology, implantology, and oral maxillofacial surgery, with growing evidence supporting its effectiveness in tissue regeneration. Fibroblasts, as central regulators of extracellular matrix synthesis and remodeling, angiogenesis, and inflammation, are important targets of PRF's regenerative effects. This review summarizes the recent evidence of role of PRF in regulation of fibroblast functions important for wound healing and inflammation. It highlights PRF as a biologically active scaffold that accelerates soft tissue repair, primarily through modulation of fibroblasts, positioning it as a promising adjunct in regenerative therapies (Figure 1).
Keywords: fibroblast functions, Inflammation, Platelet-rich fibrin, prf, Regenerative therapies, Soft tissue repair, Wound Healing
Received: 24 Oct 2025; Accepted: 15 Dec 2025.
Copyright: © 2025 Bi, Larjava and Häkkinen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lari Häkkinen
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.