REVIEW article
Front. Oral Health
Sec. Oral and Maxillofacial Surgery
This article is part of the Research TopicCurrent Trends in Oral Surgery and ImplantologyView all 8 articles
Oral Stem Cells in combination with Hydrogels as Biomimetic Bioactive Platforms for Periodontal Tissue Engineering
Provisionally accepted
Noha Taymour1
Meshari Alkandari2Mohammed Alkandari2
Md Azizul Haque3*Mohamed Ashraf El Arabi4
Gamal Atia4Hany K. Shalaby4
Omar Gamal4*
Dinesh Rokaya5*- 1Imam Abdulrahman Bin Faisal University College of Dentistry, Dammam, Saudi Arabia
- 2Kuwait Ministry of Health, Sulaibikhat, Kuwait
- 3Yeungnam University, Gyeongsan-si, Republic of Korea
- 4Suez Canal University Faculty of Dentistry, Ismailia, Egypt
- 5College of Dentistry, Ajman University, Ajman, United Arab Emirates
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Oral stem cells possess the capability to repair themselves and multipotent differentiation capacities, indicating that they have significant prospects in regenerative medicine. Nonetheless, due to the circulatory system's rapid clearance capability, they can only work consistently in certain areas for tissue healing. Thanks to their loose, porous architecture and high biocompatibility, hydrogels can act as transporters for oral stem cells, thereby delaying their release and enhancing their retention in specific regions. Oral stem cell-loaded hydrogels can be a valuable solution when specific areas require oral stem cells for optimal functioning, considering various types of hydrogels and the variables that affect their ability to transport and release oral stem cells. This review discusses the mechanistic processes underlying periodontitis, mentions current therapeutic techniques and their limitations, and explores oral stem cells and their regenerative capacities and design criteria of oral stem cells-laden hydrogels. Along with an assessment of the shortcomings in present investigations on the fundamental processes and innovative uses of oral stem cells in periodontal reconstruction, with the goal of offering fresh perspectives for upcoming research, the ongoing difficulties and disputes associated with oral stem cell-laden hydrogel personalized treatment options are also covered.
Keywords: Bone Regeneration, Engineering, Hydrogels, Oral stem cells, Periodontal
Received: 05 Nov 2025; Accepted: 29 Dec 2025.
Copyright: © 2025 Taymour, Alkandari, Alkandari, Haque, El Arabi, Atia, Shalaby, Gamal and Rokaya. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Md Azizul Haque
Omar Gamal
Dinesh Rokaya
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.