ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Gastroenterology, Hepatology and Nutrition
Volume 13 - 2025 | doi: 10.3389/fped.2025.1477711
This article is part of the Research TopicGastrointestinal and Hepatic Involvement in Cystic Fibrosis in the era of CFTR Modulator TherapiesView all 5 articles
Application of Ultrasound-guided Coaxial Needle Biopsy Combined with Gelatin Sponge Plugging in Pediatric Liver Biopsy
Provisionally accepted
- 1Department of Medical Ultrasound, West China Hospital, Sichuan University, Chengdu, China
- 2School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
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Purpose The aim of this study was to assess the performance of utilizing the coaxial technique in conjunction with gelatin sponge slurry plugging for ultrasound-guided liver biopsy in children.MethodsWe conducted a retrospective study of children undergoing ultrasound-guided coaxial liver biopsy at our institution between March 2020 and March 2025. Participants were stratified into two intervention groups: those receiving gelatin sponge tract embolization versus batroxobin administered through needle tract. Through comprehensive electronic medical record review, we systematically extracted and compared the following outcome measures: (a) overall complication rates, (b) hemorrhage rates.ResultsThis study included 48 children, with 30 allocated to the gelatin sponge group and 18 to the batroxobin group. The gelatin sponge group demonstrated 9 complications (30.0%, 9/30), consisting of 5 pain events and 4 febrile episodes, while the batroxobin group experienced 6 complications (33.3%, 6/18), including 2 hemorrhage cases, 3 pain events, and 1 febrile episode. The overall complication rates showed no statistically significant difference between groups (30.0% vs 33.3%, P=0.809). However, a significant divergence was observed in hemorrhage incidence, with the gelatin sponge group demonstrating superior safety (0% vs 11.1%, P=0.044).ConclusionCompared to batroxobin tract injection, coaxial technique in conjunction with gelatin sponge slurry plugging significantly reduced hemorrhagic complications in liver biopsies for children, demonstrating superior safety. The finding supported its adoption as the preferred hemostatic method in children undergoing percutaneous liver biopsy.
Keywords: Ultrasound guidance, Coaxial technique, Gelatin sponge particle, Children, Safety
Received: 12 Aug 2024; Accepted: 06 May 2025.
Copyright: © 2025 Zeng, Yu, Wu, Zhou and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiang Lu, Department of Medical Ultrasound, West China Hospital, Sichuan University, Chengdu, China
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