REVIEW article
Front. Pediatr.
Sec. Neonatology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1502385
Global, Regional and National Trends in the Burden of Persistent Pulmonary Hypertension of the Newborn and essentials of its management from 1993 to 2023: a scoping review
Provisionally accepted
- 1Baoan Women's and Children's Hospital, Shenzhen, China
- 2Shenzhen People's Hospital, Jinan University, Shenzhen, Guangdong Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Persistent pulmonary hypertension of the newborn (PPHN) is a common neonatal emergency in the neonatal intensive care unit (NICU) and represents a challenging condition that has not been extensively studied. PPHNremains associated with a high mortality and morbidity.Objective: We conducted this scoping review to summarize on a global scale: (1) the prevalence / incidence and etiologies of PPHN, (2) the in-hospital PPHN-related mortality rate and leading etiologies of mortality, (3) the risk factors associated with PPHN, (4) the management of PPHN. The research goal of this scoping review was not to evaluate these identified relevant studies for methodological rigor, but rather to provide a broad comprehensive global overview of PPHN, to highlight gaps in the contemporary literature and to generate directions for future research.The findings are expected to help formulate public health interventions to curb the morbidity and mortality associated with PPHN worldwide.We conducted a digital search in MEDLINE and the Cochrane Library, from January 1, 1993 to December 31, 2023.We included observational studies, interventional studies and reviews that reported sufficient data on the prevalence/incidence, mortality, predictors, etiologies, diagnosis and management of PPHN in the general neonatal population (age 0-28 days old). This process 删除[上善若水]:
Keywords: Persistent pulmonary hypertension of the newborn (PPHN), neonate, Epidemiology, Mortality, etiologies
Received: 26 Sep 2024; Accepted: 20 May 2025.
Copyright: © 2025 Huang, Yang, Liang, Chen, Zhou, Yu, Zhang and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lian Zhang, Baoan Women's and Children's Hospital, Shenzhen, China
Guichao Zhong, Shenzhen People's Hospital, Jinan University, Shenzhen, 518000, Guangdong Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.