SYSTEMATIC REVIEW article
Front. Pediatr.
Sec. Pediatric Pulmonology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1512689
Risk factors for Refractory Mycoplasma pneumoniae in Chinese Children: A Meta-Analysis
Provisionally accepted
- 1Department of Neonatology, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China
- 2Department of Emergency, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, Guangdong Province, China
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Background. With the increase of the incidence rate of Mycoplasma pneumoniae in children and the widespread use of azithromycin, the number of cases of refractory M. pneumoniae increased accordingly. M. pneumoniae infection was generally considered a self-limiting disease. However, under certain special circumstances, it was highly likely to develop into a refractory disease. This study conducted a meta-analysis of early risk factors for refractory Mycoplasma pneumoniae pneumonia (RMPP), which was helpful for the early clinical diagnosis of RMPP and the reduction of sequelae.Methods. This systematic search was conducted in Web of Science , Embase ,PubMed, Cochrane Library, CNKI, Wangfang, Sinomed and Cqvip, and the date was set until August 20, 2024.After two researchers independently screened the literature, extracted data, and assessed the risk of bias in the included studies, a meta-analysis was conducted using STATA 17.0 and RevMan 5.4 software. Results. Twenty-eight studies including 6374 patients were included in this analysis, and the results showed that the age (MD (95% CI): 0.62 (0.21, 1.03), P = 0.003), LDH (MD (95% CI
Keywords: Refractory Mycoplasma pneumoniae, Child, chil dren, Riskfactors, Meta - analysis
Received: 17 Oct 2024; Accepted: 16 Jun 2025.
Copyright: © 2025 Chen, Chen, Liu, Yang, Zhang, Wang and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yuejuan Wang, Department of Emergency, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, Guangdong Province, China
Min Cao, Department of Emergency, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, Guangdong Province, China
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