ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Pulmonology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1539218
Effectiveness of Mechanical Vibration-Assisted Sputum Clearance in Pediatric Pneumonia: A Randomized Controlled Trial with Development of an Intelligent Parameter Optimization Model
Provisionally accepted
- Wenzhou People’s Hospital, Wenzhou, China
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Background: Sputum retention in pediatric pneumonia hinders recovery. This study evaluated the therapeutic benefits of incorporating mechanical vibration-assisted sputum clearance (MVSC) as an adjunct to standard pharmacological treatment and developed a nomogram to optimize treatment parameters. Methods: In this randomized controlled trial, 160 children with pneumonia were randomly assigned (1:1) to a control group receiving pharmacological treatment or a treatment group receiving additional mechanical vibration therapy. The proportion of patients showing clinical improvement (defined as "markedly improved" or "improved") was assessed, along with symptom resolution times, lung function, blood gas parameters, and inflammatory markers, which were measured at baseline and treatment completion.LASSO regression identified predictors of clinical improvement. Results: A significantly greater proportion of patients exhibited clinical improvement in the treatment group (93.75%) compared to the control group (75%, P < 0.05). The treatment group also showed significantly shorter times for symptom resolution (pulmonary rales, fever, and cough) and hospital stay (P < 0.05). Improvements in lung function (FEV1, FEV1/FVC), blood gas parameters (PaO₂, PaCO₂, pH), and greater reductions in inflammatory markers (CRP, PCT), were observed in the treatment group (P < 0.05). A nomogram was developed using age, chest circumference, moist rales, disease severity, vibration frequency, and pressure to determine optimal mechanical vibration settings for individualized treatment. The nomogram showed high predictive accuracy (AUC = 0.943) in estimating clinical improvement, aiding in the optimization of MVSC in pediatric pneumonia.Conclusions: MVSC enhances the treatment of pediatric pneumonia, with the nomogram optimizing the parameters of the sputum clearance device.
Keywords: Pediatric pneumonia, mechanical vibration, sputum clearance, Optimizing parameters, nomogram
Received: 06 Dec 2024; Accepted: 11 Jun 2025.
Copyright: © 2025 Xue, Lin, Lin, Zhou, Dong, Chen and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tengfei Zhang, Wenzhou People’s Hospital, Wenzhou, China
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