CASE REPORT article
Front. Pediatr.
Sec. Pediatric Infectious Diseases
Volume 13 - 2025 | doi: 10.3389/fped.2025.1552232
Case report: four pediatric cases with virus-induced rhabdomyolysis; ranging from mild course to acute renal injury, hyperferritinemia and poor outcome
Provisionally accepted
- Amsterdam University Medical Center, Amsterdam, Netherlands
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We report a case-series of four healthy pediatric patients presenting with virus-induced rhabdomyolysis. Rhabdomyolysis is characterized by rapid breakdown of skeletal muscle, which can result in mild complications to acute kidney injury and even death. In children rhabdomyolysis is often virus-induced. In this case series we describe two pediatric patients with severe complications, including acute kidney injury, hyperferritinemia and even in one case liver failure and death. The rhabdomyolysis in the other two patients was caused by different viruses and had a milder presentation and good outcome after hyperhydration. Our cases highlight the variability in clinical outcome in virus-induced rhabdomyolysis. The outcome of our cases may suggest that hyperferritinemia can play a critical role in the pathophysiology of acute kidney injury and therefore may be used as an important biomarker for disease severity.
Keywords: virus-induced rhabdomyolysis, Influenza A, Hyperferritinemia, Acute kidney injure (AKI), Children
Received: 27 Dec 2024; Accepted: 23 Apr 2025.
Copyright: © 2025 Van Der Zee, Biesbroek, Oosterveld, Koot, Schoenmaker and Kuijpers. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Carlijn Van Der Zee, Amsterdam University Medical Center, Amsterdam, Netherlands
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