CASE REPORT article
Front. Pediatr.
Sec. Pediatric Pulmonology
Volume 13 - 2025 | doi: 10.3389/fped.2025.1561097
A Neonatal Case of Severe Congenital Mycoplasma Pneumoniae Pneumonia with Atelectasis and Macrolide Resistance
Provisionally accepted
- Liaocheng People's Hospital, Liaocheng, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Reports on congenital Mycoplasma pneumoniae (MP) pneumonia are rare in the medical literature. In this study, we presented a male neonatal case of severe congenital MP pneumonia complicated with atelectasis and macrolide resistance. Empirical treatment with conventional antibiotics proved ineffective, and the ventilator cannot be weaned. After experiencing five rounds of tracheal intubation, administration of fluoroquinolone antibiotics combined with bronchoscopic lavage treatment made the neonate successfully disengage from ventilator assistance. The diagnoses of this case relied on early onset of respiratory distress, atypical pneumonia manifestations presented in pulmonary imaging, characteristic mucous plugs associated with MP observed during bronchoscopy, and positive MP nucleic acid and IgG antibody in the neonate and his mother. Importantly, this case report provided clinical evidence on the treatment of congenital MP infection with atelectasis and macrolide resistance by administrating fluoroquinolones in proper dosages and courses and adopting bronchoscopic lavage as an effective treatment choice to clear airway obstruction and improve pulmonary ventilation function.
Keywords: Mycoplasma pneumoniae pneumonia, Atelectasis, macrolide resistance, Fluoroquinolone antibiotic, Bronchoscopic lavage
Received: 15 Jan 2025; Accepted: 14 May 2025.
Copyright: © 2025 Wang, Yang, Qin, Wang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jing Zhao, Liaocheng People's Hospital, Liaocheng, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.